Biological evaluation of hydroxyapatite zirconium nanoparticle as a potential radiosensitizer for lung cancer X-ray induced photodynamic therapy.

Photodynamic therapy has been recognized as a viable approach for lung cancer treatment. Some photosensitizer agents are known as X-ray sensitive and could improve radiotherapy efficacy. The use of nanoparticles for drug delivery and as photosensitizer agents offers various advantages because of their rapid cellular accumulation and distribution into target organs.

New hybrid radio-fluorescent probes [I]-BPF-01 and [I]-BPF-02 for visualisation of cancer cells: Synthesis and preliminary in vitro and ex vivo evaluations.

We synthesised and biologically evaluated two new hybrid probes and which were built from three structural entities: benzothiazole-phenyl, fluorescein isothiocyanate (FITC), and iodine-131. These probes were designed for potential applications in assisting surgical procedures of solid cancers. The cytotoxicity study demonstrated that fluorescent probes (31.

Estrogen receptor targeting with genistein radiolabeled Technetium-99 as radiotracer of breast cancer: Its optimization, characterization, and predicting stability constants by DFT calculation.

Objective: Genistein is an isoflavone molecule with a high affinity for estrogen receptors (ER), which could lead to the mechanism of selective estrogen receptor modulators (SERMs) in breast cancer. Genistein labeling with technetium-99 can be a new promising strategy for diagnostic breast cancer. In this research, we evaluate the physicochemical characteristics of the [Tc]Tc-genistein complex and describe the optimal labeling method parameters.

Iodine-131 labeled genistein as a potential radiotracer for breast cancer.

Objective: Genistein is an isoflavone compound that has been proven to have anticancer activity and is capable of binding to estrogen β receptors with Selective Estrogen Receptor Modulators (SERMs) properties, and has a strong affinity to inhibit the development of cancer cells. This study is to determine the optimum conditions of the reaction in the synthesis process of compounds labeled I-genestein which can be potential for application of breast cancer diagnosis.

Methods: Synthesis of I-Genistein compound labeling using the Chloramine-T iodination method.

The optimization method for synthesis of technetium-99m-luteolin as radiotracer in the development of cancer drugs from flavonoid.

The aim of this study is to find the optimum conditions of labeling luteolin flavonoid compounds with technetium-99m (Tc) to meet the purity requirements stated in the United States Pharmacopeia. This compound is expected to be a potential radiotracer compound for diagnosing cancer. The optimization method in labeling luteolin with technetium determines the parameters such as pH, SnCl.

Technetium-99m-labeled genistein as a potential radical scavenging agent.

The purpose of this study was to determine the optimum conditions for labeling genistein compounds with technetium-99m (Tc) radionuclides and the percentage of purity obtained in accordance with the requirements of the United State Pharmacopeia. The method used is optimization of several parameters including pH, SnCl.2HO as reducing agents, genistein concentration, and incubation time.