Publications by authors named "Maud Eline Ottenheijm"
Background: The molecular mechanisms underlying development of posthemorrhagic hydrocephalus (PHH) following subarachnoid hemorrhage (SAH) remain incompletely understood. Consequently, treatment strategies tailored towards the individual patient remain limited. This study aimed to identify proteomic cerebrospinal fluid (CSF) biomarkers capable of predicting shunt dependency and functional outcome in patients with SAH in order to improve informed clinical decision making.
View Article and Find Full Text PDFMultisystem inflammatory syndrome in children (MIS-C) is a severe disease that emerged during the COVID-19 pandemic. Although recognized as an immune-mediated condition, the pathogenesis remains unresolved. Furthermore, the absence of a diagnostic test can lead to delayed immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- The study aims to uncover the biological mechanisms behind ventricular fibrillation (VF) during the first ST-elevation myocardial infarction (STEMI) by identifying associated proteins.
- Researchers analyzed plasma samples from 229 STEMI patients (110 with VF and 120 without) using mass spectrometry, quantifying around 257 proteins per patient and identifying 26 that were linked to VF.
- Two proteins, ACTBL2 and F13A1, showed significant up-regulation associated with VF, suggesting potential new molecular mechanisms and warranting further investigation for their role as biomarkers or responses during acute ischemia.