Publications by authors named "Maud Debaugnies"
Article Synopsis
- Cancer cell resistance to therapy leads to high mortality rates among patients, with epithelial-to-mesenchymal transition (EMT) linked to this resistance.
- A study using a mouse model revealed that EMT cancer cells show strong resilience against various anti-cancer treatments due to the action of RHOJ, a small GTPase predominantly found in these cells.
- RHOJ enhances the tumor cells' ability to handle DNA damage from chemotherapy by promoting their response to stress and maintaining DNA repair mechanisms, indicating its critical role in EMT-associated therapy resistance.
YAP and TAZ are key downstream regulators of the Hippo pathway, regulating cell proliferation and differentiation. YAP and TAZ activation has been reported in different cancer types. However, it remains unclear whether they are required for the initiation of major skin malignancies like basal cell carcinoma (BCC) and squamous cell carcinoma (SCC).
View Article and Find Full Text PDFThe accurate maintenance of genomic integrity is essential for tissue homeostasis. Deregulation of this process leads to cancer and aging. BRCA1 is a critical mediator of this process.
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