Publications by authors named "Mauber Eduardo Schultz Moreira"
Evaluation of chemotherapy toxicities in patients receiving treatment for gastrointestinal cancers and therapeutic monitoring of 5-fluorouracil as a clinical support tool.
Fundam Clin Pharmacol
December 2024
Article Synopsis
- 5-Fluorouracil (5-FU) is commonly used to treat gastrointestinal cancers, but severe toxicity can occur due to exposure factors related to the DPD enzyme, which is influenced by the DPYD gene.
- A study involving 47 patients assessed their 5-FU plasma levels, DPD activity, and DPYD gene variations to explore possible correlations with toxicity.
- Results indicated high rates of anemia and neutropenia among patients, with many having plasma levels outside the therapeutic range, suggesting a need for personalized treatment strategies based on DPD assessments to minimize toxicity risks.
In this work, we investigated the stability of arsenic trioxide (ATO) used in leukemia treatment, encapsulated with nanoliposome, with the aid of ultrasound treatment. Stability studies of As species were followed by liquid chromatography-inductively coupled plasma mass spectrometry (LC-ICP-MS), allowing for the detection of the conversion of low amounts of As(III) to As(V) or the formation of other As species. The influence of storage temperature and time on ATO was evaluated.
View Article and Find Full Text PDFLowered Cisplatin Dose and No Bleomycin in the Treatment of Pediatric Germ Cell Tumors: Results of the GCT-99 Protocol From the Brazilian Germ Cell Pediatric Oncology Cooperative Group.
J Clin Oncol
February 2016
Purpose: We describe the results of a risk-adapted, response-based therapeutic approach from the Brazilian GCT-99 study on germ cell tumors.
Patients And Methods: From May 1999 to October 2009, 579 participants were enrolled in the Brazilian GCT-99 study. Treatment, defined as specific chemotherapy regimen and number of cycles, was allocated by means of risk-group assignment at diagnosis with consideration for stage and primary tumor site.
High frequency of t(12;21)(p13;q22) in children with acute lymphoblastic leukemia and known clinical outcome in southern Brazil.
Leuk Res
October 2004
The presence of the t(12;21)(p13;q22) distinguishes a subset of children with acute lymphoblastic leukemia (ALL) that present a favorable prognosis. This is a cryptic translocation difficult to detect through conventional cytogenetics. In this study, bone marrow samples from 30 children with ALL from southern Brazil were evaluated by fluorescence in situ hybridization (FISH) for the t(12;21), using locus specific probes to detect the TEL/AML1 rearrangement.
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