Outcomes and Perioperative Complications of Surgical Resection on Canine Carotid Paragangliomas (21 Cases): A Veterinary Society of Surgical Oncology Study.

Carotid body paragangliomas represent an uncommon neoplasm in dogs. The objective of this study was to report outcomes and complications associated with surgical excision of carotid body paragangliomas in 21 dogs. Cases were recruited retrospectively via medical record review from 9 veterinary speciality centres.

Case report: Palliation of right pulmonary artery compression with overlapping, self-expanding vascular stents and toceranib phosphate in a dog with a large, compressive chemodectoma.

Acquired pulmonary artery branch stenosis without main pulmonary artery involvement due to external compression by neoplasia has been described in human and veterinary medicine. Over time, this can result in right ventricular hypertension and right-sided heart failure. Endovascular stenting offers quick relief from signs, while the underlying cause is addressed.

Comparison of Bending Stiffness between String of Pearls Plate-Bone Substitute Constructs with and without Bending Tees in a Fracture Gap Model.

Objective:  The aim of this study was to compare the bending properties of String of Pearls plate-bone substitute constructs with and without bending tees in the nodes over a simulated fracture gap. It is hypothesized that the constructs with tees will have higher bending stiffness.

Study Design:  Acetal polymer tubes and 12-hole, 3.

Treatment of retroperitoneal sarcoma results in improved outcomes.

Objective: To report the clinical characteristics, treatments, and outcomes in a cohort of dogs with histologically confirmed retroperitoneal sarcoma (RPS) and to identify potential variables of prognostic significance.

Animals: 46 client-owned dogs from 10 clinics with histopathologic diagnosis of a sarcoma originating from the retroperitoneal space.

Methods: Medical records were retrospectively reviewed to obtain information regarding clinical characteristics, treatments, and outcomes.

Single-Nuclei Multiome (ATAC + Gene Expression) Sequencing of a Primary Canine Osteosarcoma Elucidates Intra-Tumoral Heterogeneity and Characterizes the Tumor Microenvironment.

Osteosarcoma (OSA) is a highly aggressive bone tumor primarily affecting pediatric or adolescent humans and large-breed dogs. Canine OSA shares striking similarities with its human counterpart, making it an invaluable translational model for uncovering the disease's complexities and developing novel therapeutic strategies. Tumor heterogeneity, a hallmark of OSA, poses significant challenges to effective treatment due to the evolution of diverse cell populations that influence tumor growth, metastasis, and resistance to therapies.

Transvalvular Pulmonary Stent Angioplasty for Management of an Intraluminal, Compressive Chemodectoma in a Dog.

• Chemodectomas are a common type of heart-base mass in dogs. • Chemodectomas may cause compression or invasion of adjacent structures. • Vascular stent placement may improve blood flow across a vascular obstruction.

Staphylectomy in nonbrachycephalic dogs: A retrospective study of 27 cases.

Objective: To report the outcomes and complications associated with staphylectomy in nonbrachycephalic dogs.

Animal: Twenty-seven nonbrachycephalic dogs with elongated soft palates and undergoing staphylectomy.

Procedure: Retrospective study.

Indirect lymphography for sentinel lymph node detection in dogs with mast cell tumors.

Objective: The objective of this report is to describe the technique and diagnostic utility of indirect lymphography (IL) using water-soluble contrast for sentinel lymph node (SLN) mapping in dogs with mast cell tumors.

Animals: Fifty-three dogs with 59 mast cell tumors were included.

Procedure: Medical records were retrieved for dogs with a cytological diagnosis of mast cell tumor which also had IL performed for lymph node mapping.

Outcomes and clinical features associated with surgically excised canine salivary gland carcinoma: A multi-institutional, retrospective, Veterinary Society of Surgical Oncology study.

Objective: The objective of this study was to describe the clinical features, prognostic factors, and outcomes in dogs with surgically treated salivary gland carcinoma.

Study Design: Multi-institutional retrospective case series.

Animals: Seventy-two client-owned dogs from 16 institutions with surgically excised salivary gland carcinoma.

Outcome in 38 dogs surgically treated for hepatic abscessation.

Objective: To report outcomes following surgical treatment of hepatic abscessation in dogs.

Study Design: Retrospective.

Animals: Thirty-eight dogs.

Evaluation of zoledronate for the treatment of canine stage III osteosarcoma: A phase II study.

Background: Greater than 90% of dogs with appendicular osteosarcoma will develop pulmonary metastasis despite the standard of care. Available treatments have limited efficacy for stage III disease. Zoledronate, a bisphosphonate, induces apoptosis of canine osteosarcoma cells and appears to modulate the tumour microenvironment.

Transcriptomic Analysis of Canine Osteosarcoma from a Precision Medicine Perspective Reveals Limitations of Differential Gene Expression Studies.

Despite significant advances in cancer diagnosis and treatment, osteosarcoma (OSA), an aggressive primary bone tumor, has eluded attempts at improving patient survival for many decades. The difficulty in managing OSA lies in its extreme genetic complexity, drug resistance, and heterogeneity, making it improbable that a single-target treatment would be beneficial for the majority of affected individuals. Precision medicine seeks to fill this gap by addressing the intra- and inter-tumoral heterogeneity to improve patient outcome and survival.

Pathology in Practice.

In collaboration with the American College of Veterinary Pathologists.

Influence of stapler type on leakage pressures and location of functional end-to-end stapled anastomoses.

The objective of this study was to compare maximal leakage pressures and locations of 2 functional end-to-end stapled anastomosis (FEESA) constructs. Grossly normal jejunum was harvested from 4 large breed dogs. Thirty-two 8-cm segments of bowel were used to construct 16 FEESA.

Dogs ≥ five years of age at the time of congenital extrahepatic portosystemic shunt diagnosis have better long-term outcomes with surgical attenuation than with medical management alone.

Objective: To determine the outcome in dogs diagnosed with congenital extrahepatic portosystemic shunts (EHPSS) at ≥ 5 years of age treated with medical management only (M) or with surgical attenuation (S). The hypothesis was that dogs undergoing surgical attenuation would have a longer survival time than dogs undergoing medical management only.

Animals: 351 dogs definitively diagnosed with EHPSS at ≥ 5 years of age.

Ex vivo comparison of different thoracoabdominal stapler sizes for typhlectomy in canine cadavers.

Objective: To determine the influence of staple size on leakage pressure of typhlectomy sites in canine cadavers.

Study Design: Randomized, experimental cadaveric study.

Animals: Twenty-four fresh canine cadavers.

Partial parotid sialoadenectomy in a horse with parotid ductal carcinoma: Surgical description and case report.

Objectives: To describe the surgical findings, histopathological features, and long-term outcome for a horse with parotid salivary carcinoma.

Study Design: Case report ANIMALS: Twelve year old American Quarter Horse gelding.

Methods: The gelding was presented for a 10 × 10 cm swelling below the base of the right ear.

Outcome and postoperative complications in 73 dogs with thyroid carcinoma with gross vascular invasion managed with thyroidectomy.

Excellent outcomes have been reported following thyroidectomy for thyroid carcinoma in dogs, but outcomes for thyroid carcinomas with gross vascular invasion are poorly described. This study describes the clinical outcomes and complications in dogs with thyroid carcinomas with gross vascular invasion undergoing thyroidectomy. Medical records of dogs that underwent thyroidectomy between January 1st 2010 and December 31st 2019 were reviewed at 10 hospitals.

Evaluation of tumor immunity after administration of conditionally replicative adenoviral vector in canine osteosarcoma patients.

Osteosarcoma is one among the most common neoplasms in dogs. Current treatments show limited efficacy and fail to prevent metastasis. Conditionally replicative adenoviruses (CRAd) replicate exclusively in targeted tumor cells and release new virus particles to infect additional cells.

Predictive ability of fine-needle aspirate cytology for incompletely resected mast cell tumor surgical sites.

The goal of this study was to evaluate whether fine-needle aspirate cytology of a previous surgical site was predictive of recurrence for incompletely excised mast cell tumors (MCTs). Electronic medical records were searched for dogs diagnosed with MCTs; those with histologically confirmed, incompletely resected MCTs evaluated by scar aspiration cytology within 60 days after surgery were included for analysis. Variables were compared between groups using Fisher's exact test and logistic regression.