Publications by authors named "Mattia Giovenzana"
Article Synopsis
- Ketamine may help improve resilience to stress and prevent related disorders, but its specific molecular targets, particularly the role of p11 protein, are still being studied.
- Research showed that administering ketamine prior to stress exposure can mitigate negative effects and disturbances in brain metabolism related to stress.
- The study found that p11 is crucial for the effectiveness of ketamine in promoting resilience, as its absence in serotonergic neurons led to increased vulnerability to stress-related depression.
Glutamate is the main excitatory neurotransmitter in the brain wherein it controls cognitive functional domains and mood. Indeed, brain areas involved in memory formation and consolidation as well as in fear and emotional processing, such as the hippocampus, prefrontal cortex, and amygdala, are predominantly glutamatergic. To ensure the physiological activity of the brain, glutamatergic transmission is finely tuned at synaptic sites.
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