Neurofibromin Expression is Associated with Aggressive Disease and Poor Outcome in Colorectal Carcinoma.

Aim: To assess the predictive and prognostic value of neurofibromin (NF) expression in colorectal carcinoma (CRC).

Materials And Methods: The present series consists of archival samples from 191 patients with stage I, II, III, or IV CRC treated between 1981 and 1990 at the Turku University Hospital (Finland). Tumor biopsies as microarray blocks were analyzed for expression of NF by immunohistochemistry.

High cyclooxygenase-2 expression is associated with advanced stages in colorectal cancer.

Background: Despite compelling evidence from the genetic background and clinical studies indicating that cyclooxygenase-2 (COX2) up-regulation is a key step in carcinogenesis of colorectal carcinoma (CRC), controversy regarding its role as a prognostic factor exists. However, all evidence indicates that increased COX2 activity promotes progression of CRC. This study, aimed to evaluate the expression of COX2 in CRC, and correlate it with different patient clinicopathological data, emphasizing on the role of COX2 as a prognostic factor for CRC.