Imiquimod in the treatment of eyelid basal cell carcinoma.

Purpose: To assess the efficacy and safety of topical imiquimod 5% cream in the treatment of eyelid basal cell carcinoma.

Methods: Four patients with eyelid basal cell carcinoma were treated with imiquimod once daily, 5 days per week, for 6 weeks. Tissue biopsy was taken and clinical examination with slit-lamp microscopy was performed at the beginning of the study and after a follow-up of 12 weeks.

Asymmetric dimethylarginine is not elevated in exfoliation syndrome but symmetric dimethylarginine is related to exfoliative glaucoma.

Background: Hyperhomocysteinemia (HH), oxidative stress and endothelial dysfunction are all implicated as possible pathogenetic factors in exfoliation syndrome (XFS) and exfoliative glaucoma (XFG). Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of endothelial nitric oxide and plasma level of ADMA is often elevated in HH. Thus the present study was undertaken to study plasma levels of ADMA with concomitant measurement of symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) in XFS and XFG.

Geldanamycin increases 4-hydroxynonenal (HNE)-induced cell death in human retinal pigment epithelial cells.

Development of age-related macular degeneration (AMD) is associated with functional abnormalities and cell death in retinal pigment epithelial (RPE) cells attributable to oxidative stress. To minimize the adverse effects of oxidative stress, cells activate their defence systems, e.g.

Simultaneous bilateral cataract surgery: a retrospective survey.

Purpose: To evaluate patient satisfaction and functional visual outcome, safety, and visual and refractive outcomes of simultaneous bilateral cataract surgery (SBCS).

Setting: North Karelia Central Hospital, Joensuu, Finland.

Methods: A retrospective external review of 200 patients drawn randomly from 637 patients who underwent SBCS at the North Karelia Central Hospital in 2001 was performed.

Plasma and aqueous humour levels of homocysteine in exfoliation syndrome.

Background: Recent studies have suggested that the relationship between elevated plasma homocysteine (Hcy) and increased risk of vascular disease holds also for certain diseases of the eye with vascular aetiology. Elevated plasma Hcy levels have been noted among patients with exfoliation syndrome (XFS). The purpose of this study was to establish whether subjects with XFS have higher plasma and aqueous humour Hcy levels values than non-XFS subjects, particularly in relation to vitamin B status.