[Respiratory disturbance during sleep induced by vagus nerve stimulator].

Vagus nerve stimulation can be used in parallel with drug therapy as adjuvant therapy for severe epilepsy. In approximately half of the patients the number of seizures decreases by at least 50%. The most common adverse effects reported for the therapy include mild laryngeal and upper respiratory tract symptoms and dysfunctions, and in some cases, also development of respiratory disturbances during sleep.

Childhood-onset epilepsy five decades later. A prospective population-based cohort study.

Objective: To study the impact of childhood-onset epilepsy on a variety of outcomes across the life span.

Methods: A population-based cohort of 245 subjects with childhood-onset epilepsy was assessed for outcomes at 45 years. In addition, 51 of 78 surviving subjects with uncomplicated epilepsy and 52 of 99 originally matched controls participated in a detailed evaluation including electroencephalography (EEG), imaging, and laboratory studies at 50 years.

Neurological symptoms and natural course of xeroderma pigmentosum.

We have prospectively followed 16 Finnish xeroderma pigmentosum (XP) patients for up to 23 years. Seven patients were assigned by complementation analysis to the group XP-A, two patients to the XP-C group and one patient to the XP-G group. Six of the seven XP-A patients had the identical mutation (Arg228Ter) and the seventh patient had a different mutation (G283A).