Publications by authors named "Matthieu de Kalbermatten"
Article Synopsis
- The study aims to assess the safety and efficacy of using expanded CD34+ cells for treating patients with acute myocardial infarction (AMI) and reduced left ventricular function, crucial for improving patient outcomes.
- Patients with severe AMI (left ventricular ejection fraction <50%) are randomly assigned to receive either CD34+ cell treatment alongside standard care or standard care only, with a focus on monitoring major adverse cardiac events over six months.
- This trial is groundbreaking as it explores the automated expansion and administration of autologous CD34+ cells, addressing current technological limitations in cell therapy for heart recovery post-AMI.
Article Synopsis
- Stem cell transplantation is a potential therapy for stroke that could be applied at various times post-stroke, but challenges remain regarding the identification of effective donor stem cells and their mechanisms of action.
- The study highlights ProtheraCytes, a type of CD34+ cells from human blood and umbilical cords, which have shown promise in a clinical trial and are found to secrete growth factors that aid in blood vessel formation.
- Experimental results in rats demonstrate that intranasal delivery of ProtheraCytes after a stroke significantly improved recovery and reduced brain damage, with indicators suggesting the role of specific extracellular vesicles (CD63+ EVs) in promoting regeneration and reducing inflammation.
Stroke is a leading cause of death in the US and around the world but with limited treatment options. Survivors often present with long-term cognitive and neurological deficits. Stem cell-based therapy has emerged as a potential treatment for stroke.
View Article and Find Full Text PDFKnee osteoarthritis (OA) is a degenerative joint disease of the knee that results from the progressive loss of articular cartilage. It is most common in the elderly and affects millions of people worldwide, leading to a continuous increase in the number of total knee replacement surgeries. These surgeries improve the patient's physical mobility, but can lead to late infection, loosening of the prosthesis, and persistent pain.
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