Publications by authors named "Matthieu M Vermeren"
Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants.
Immunity
April 2020
Article Synopsis
- The omentum is a fat-rich tissue that plays a crucial role in immune defense by capturing contaminants in the abdominal cavity during conditions like peritonitis.
- Single-cell RNA sequencing uncovered that the surface of fat-associated lymphoid clusters (FALCs) is lined with specific cells called CXCL1 mesothelial cells, which are vital for recruiting neutrophils.
- Blocking CXCL1 or inhibiting certain enzymes significantly reduced neutrophil activity and contaminant capture, highlighting the specialized role of these cells in immune responses to infection.
A lack of regulatory T cell function is a critical factor in the pathogenesis of autoimmune diseases, such as multiple sclerosis (MS). Ligation of the complement regulatory protein CD46 facilitates the differentiation of T helper 1 (T1) effector cells into interleukin-10 (IL-10)-secreting type 1 regulatory T cells (Tr1 cells), and this pathway is defective in MS patients. Cleavage of the ectodomain of CD46, which contains three N-glycosylation sites and multiple O-glycosylation sites, enables CD46 to activate T cells.
View Article and Find Full Text PDFPhospholipase D2 (PLD2) is an enzyme that produces phosphatidic acid (PA), a lipid messenger molecule involved in a number of cellular events including, through its membrane curvature properties, endocytosis. The PLD2 knock out (PLD2KO) mouse has been previously reported to be protected from insult in a model of Alzheimer's disease. We have further analysed a PLD2KO mouse using mass spectrophotometry of its lipids and found significant differences in PA species throughout its brain.
View Article and Find Full Text PDF