Publications by authors named "Matthieu Cornet"
Article Synopsis
- Cystic Fibrosis (CF) is a disease caused by problems with a specific protein in our cells, and it's not just about that one protein being broken.
- Researchers are using a complex method to understand how the lack of this protein disrupts important processes in cells and causes health issues.
- The study found important proteins that could help attack CF and suggested new ways to treat it, which might also help with other rare diseases in the future.
Article Synopsis
- Children with cystic fibrosis (CF) often face acute respiratory failure due to severe pulmonary exacerbations, leading to pediatric intensive care unit (PICU) admissions, with a focus on understanding their short and medium-term outcomes.
- A study reviewed data from patients under 18 years old admitted to a French PICU over two decades, utilizing statistical methods to identify factors influencing mortality and the need for lung transplants.
- Results indicated high mortality rates (up to 41% within 3 years post-discharge) and identified key risk factors like gender, certain blood gas levels, and pre-admission health conditions, highlighting the critical need for early consideration of lung transplants as a survival option.
The efficiency of analyzing high-throughput data in systems biology has been demonstrated in numerous studies, where molecular data, such as transcriptomics and proteomics, offers great opportunities for understanding the complexity of biological processes. One important aspect of data analysis in systems biology is the shift from a reductionist approach that focuses on individual components to a more integrative perspective that considers the system as a whole, where the emphasis shifted from differential expression of individual genes to determining the activity of gene sets. Here, we present the rROMA software package for fast and accurate computation of the activity of gene sets with coordinated expression.
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- Some people with Cystic Fibrosis (CF) also have a rare skin problem called aquagenic palmoplantar keratoderma, but it's unclear why this happens.
- Researchers studied the sweat of 25 CF patients and 12 healthy people to find out what proteins were different in their sweat.
- They found 57 proteins that were different; many were increased in CF patients, suggesting issues with their skin barrier and that this information might help in treating CF better.
Introduction: Clinical trials for CFTR modulators consider mean changes of clinical status at the cohort level, and thus fail to assess the heterogeneity of the response. We aimed to study the different response profiles to lumacaftor-ivacaftor according to age in children with cystic fibrosis (CF).
Methods: A mathematical framework, including principal component analysis, data clustering, and data completion, was applied to a multicenter cohort of 112 children aged 6-18 years, treated with lumacaftor-ivacaftor.