Publications by authors named "Matthieu Buscot"
Introduction: COVID-19 vaccines are expected to provide effective protection. However, emerging strains can cause breakthrough infection in vaccinated individuals. The immune response of vaccinated individuals who have experienced breakthrough infection is still poorly understood.
View Article and Find Full Text PDFWe describe a rare case of severe disseminated monkeypox (MPox) virus infection complicated by peritonitis in a 44-year-old man living with well-controlled HIV. The patient was successfully treated with tecovirimat without requiring surgery. MPox should be considered in the differential diagnosis of non-bacterial peritonitis in patients at risk of infection.
View Article and Find Full Text PDFBackground: Cardiac injury has been reported in up to 30% of coronavirus disease 2019 (COVID-19) patients. However, cardiac injury is defined mainly by troponin elevation without description of associated structural abnormalities and its time course has not been studied.
Research Question: What are the ECG and echocardiographic abnormalities as well as their time course in critically ill COVID-19 patients?
Study Design And Methods: The cardiac function of 43 consecutive COVID-19 patients admitted to two ICUs was assessed prospectively and repeatedly, combining ECG, cardiac biomarker, and transthoracic echocardiographic analyses from ICU admission to ICU discharge or death or to a maximum follow-up of 14 days.
Article Synopsis
- New treatments for idiopathic pulmonary fibrosis (IPF) are needed due to the lack of effective options, with a focus on understanding lung fibroblast activation, the main factor in fibrosis.
- The study identifies DNM3OS, a long noncoding RNA, as a crucial regulator of TGF-β-induced differentiation of lung fibroblasts into myofibroblasts, which contributes to fibrosis.
- Targeting DNM3OS and its associated microRNAs showed promise in preventing and even reversing pulmonary fibrosis, highlighting potential new therapeutic strategies for IPF.
Article Synopsis
- Recent guidelines recommend using non-invasive ventilation (NIV) to prevent respiratory failure in ICU patients after extubation, but the evidence is not very strong; high-flow nasal cannula (HFNC) is considered effective as well.
- The study will compare the effectiveness of HFNC alone versus HFNC combined with NIV in reducing reintubation rates among high-risk patients in the ICU.
- The trial will include 600 participants, measuring outcomes like reintubation rates and ICU stay length, with ethics approval and plans for future publication.
respiratory infection is usually mild and self-limiting. We report a case of acute respiratory distress syndrome (ARDS) due to infection in a 60 years old woman. Quick diagnosis was established by multiplex PCR assay for detection of pneumonia-causing bacteria.
View Article and Find Full Text PDFCapsule endoscope aspiration is an increasingly reported complication, potentially responsible for respiratory distress and asphyxia. This adverse event is primarily managed by rigid bronchoscopy when spontaneous expulsion does not occur. This complication is all the more detrimental to patients as it can delay or jeopardize further digestive exploration.
View Article and Find Full Text PDFBackground: Data concerning phenotypes in bronchiectasis are scarce.
Objective: The aim of this study was to describe the clinical, functional and microbiological phenotypes of patients with bronchiectasis.
Methods: A monocentric retrospective study in a university hospital in France was conducted over 10 years (2002-2012).