Inter- and intraspecific diversity of Salix bark phenolic profiles - A resource for the pharmaceutical industry.

Due to their content of phenolic compounds, willow bark preparations are used as an herbal remedy. The large diversity of phenolic secondary metabolites in Salix still provides a resource for the identification of bioactive compounds in particular species, including species not yet in focus from a phytopharmaceutical perspective. The present study describes the bark phenolic profile of 13 Salix species analyzed by HPLC-MS: Salix alba, Salix babylonica, Salix daphnoides, Salix fragilis, Salix hastata, Salix myrsinifolia, Salix pentandra, Salix purpurea, Salix repens (including subspecies S.

Identification of Salicylates in Willow Bark ( Cortex) for Targeting Peripheral Inflammation.

cortex-containing medicine is used against pain conditions, fever, headaches, and inflammation, which are partly mediated via arachidonic acid-derived prostaglandins (PGs). We used an activity-guided fractionation strategy, followed by structure elucidation experiments using LC-MS/MS, CD-spectroscopy, and 1D/2D NMR techniques, to identify the compounds relevant for the inhibition of PGE release from activated human peripheral blood mononuclear cells. Subsequent compound purification by means of preparative and semipreparative HPLC revealed 2'--acetylsalicortin (), 3'--acetylsalicortin (), 2'--acetylsalicin (), 2',6'--diacetylsalicortin (), lasiandrin (), tremulacin (), and cinnamrutinose A ().

Chemoprofiling as Breeding Tool for Pharmaceutical Use of .

Willow bark is traditionally used for pharmaceutical purposes. Evaluation is so far based on the salicylate content, however, health promoting effects of extracts might be attributed to the interaction of those salicylates with other compounds, which support and complement their action. So far, only , , and are included in pharmaceutical extracts.

Compound-specific responses of phenolic metabolites in the bark of drought-stressed Salix daphnoides and Salix purpurea.

The bark of willows (Salix spp.) is rich in bioactive phenolic compounds from different compound classes and is therefore used as an herbal remedy. The accumulation of these secondary plant metabolites is influenced by environmental factors, including the availability of water.

Melampsora rust species on biomass willows in central and north-eastern Germany.

Melampsora willow rusts are the most important fungal pathogens in short rotation coppices of biomass willows. In the past, breeding programmes for rust resistant biomass willows concentrated on the distinction of races within the forma specialis Melampsora larici-epitea f. sp.

Factors influencing the variability of antioxidative phenolic glycosides in Salix species.

Phenolic glycosides, especially the salicylates, are important secondary metabolites in the bark of willows (Salix spp.). Because of their anti-inflammatory, analgesic, and fever-reducing properties, they are of particular interest to society.