Influence of light filters in intraocular lenses on color perception and contrast acuity.

Purpose: To compare contrast acuity at different illumination levels, color vision, and the subjective visual impression in patients after bilateral cataract surgery with mixed implantation of a yellow-tinted intraocular lens (IOL) and an orange-tinted IOL.

Setting: Department of Ophthalmology, Hietzing Hospital, Vienna, Austria.

Design: Prospective case series.

Effect of a single-piece and a three-piece acrylic sharp-edged IOL on posterior capsule opacification.

Background: To compare the intensity of posterior capsule opacification (PCO) between two intraocular lenses (IOLs) of the same optic material, but with different haptic design (1-piece vs. 3-piece).

Methods: This prospective intraindividual controlled cohort study comprised eighty eyes of 40 patients with bilateral age-related cataract.

Influence of blue-light-filtering intraocular lenses on color perception and contrast acuity.

Purpose: To compare contrast acuity at different illumination levels and color vision and the subjective impression in patients after bilateral cataract surgery with a mixed implantation of a blue-light-filtering and an ultraviolet (UV)-filtering intraocular lens (IOL).

Design: Randomized, controlled, double-masked, and bilateral study with intraindividual comparison.

Participants: This study included 48 eyes of 24 consecutive patients with age-related cataract.

Effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Objective: To investigate the effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Design: Randomized, placebo-controlled, double-masked, 2-drug crossover study with 10 patients with cornea guttata and 10 healthy controls, who had mean endothelial cell counts of 988 and 2377 cells/mm(2), respectively. Study medications were 2% dorzolamide and placebo drops applied 3 times a day for 4 weeks.

Intraocular pressure rise after primary posterior continuous curvilinear capsulorhexis with a fixed dorzolamide-timolol combination: randomized safety study with intraindividual comparison using an angulated and a nonangulated intraocular lens.

Purpose: To assess the safety, in terms of the intraocular pressure (IOP), of cataract surgery with primary posterior continuous curvilinear capsulorhexis (PPCCC) and a postoperative dose of a fixed dorzolamide-timolol combination and evaluate the effect of intraocular lens (IOL) haptic angulation.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: In this prospective randomized double-masked bilateral study, 88 eyes of 44 consecutive patients with age-related cataract were included in an intraindividual comparison study.

Ultrahigh resolution optical coherence tomography of macular holes.

Purpose: To evaluate ultrahigh resolution optical coherence tomography (UHR OCT) for visualization of intraretinal layers, especially the photoreceptor inner segment and outer segment layers, in eyes with macular holes and after surgical intervention.

Methods: An UHR OCT system based on a titanium:sapphire laser was used, enabling in vivo cross-sectional retinal imaging with 3-micro m axial resolution. Typical, representative tomograms of 5 of 48 eyes from 36 patients demonstrated the potential of UHR OCT to detect morphologic changes in different stages of full-thickness macular holes and changes induced by surgical intervention.

Effect of anterior capsule polishing on the posterior capsule opacification-inhibiting properties of a sharp-edged, 3-piece, silicone intraocular lens: three- and 5-year results of a randomized trial.

Purpose: To evaluate the long-term effects of anterior capsule polishing on regeneratory posterior capsule opacification (PCO), anterior capsule opacification (ACO), and fibrotic PCO with a silicone intraocular lens (IOL) with sharp optic edges.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: This prospective bilateral randomized patient- and examiner-masked clinical trial comprised 130 eyes of 65 patients with bilateral age-related cataract.

Effect of anterior capsule polishing on posterior capsule opacification and neodymium:YAG capsulotomy rates: three-year randomized trial.

Purpose: To compare the long-term effect of extensive polishing and nonpolishing of the anterior lens capsule on posterior capsule opacification (PCO) and neodymium:YAG (Nd:YAG) capsulotomy rates.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: This prospective randomized bilateral double-masked study included 108 eyes of 54 consecutive patients with age-related cataract.

Ultrahigh resolution optical coherence tomography in macular dystrophy.

Purpose: To visualize and investigate intraretinal changes in macular dystrophies with ultrahigh resolution optical coherence tomography (UHR OCT).

Design: Prospective observational case series.

Methods: setting: Department of Ophthalmology and Center for Biomedical Engineering and Physics, Christian Doppler Laboratory, Medical University of Vienna, Vienna, Austria.

Pilocarpine-induced shift of an accommodating intraocular lens: AT-45 Crystalens.

Purpose: To measure the shift of an accommodating plate-haptic intraocular lens (IOL) along the visual axis induced by ciliary muscle contraction after application of pilocarpine.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: Fifty-four eyes of 28 patients with age-related cataract comprised this prospective study.

Long-term effect of optic edge design in an acrylic intraocular lens on posterior capsule opacification.

Purpose: To compare the posterior capsule opacification (PCO) inhibiting effect of the sharp posterior optic edge design of the Sensar OptiEdge AR40e intraocular lens (IOL) with that of the double-round edge design of the Sensar AR40 IOL over a period of 3 years.

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: Fifty-three patients with bilateral age-related cataract (106 eyes) were included in this randomized prospective bilateral patient- and examiner-masked clinical trial with intraindividual comparison.

Primary silicone oil tamponade without retinopexy in highly myopic eyes with central macular hole detachments.

Background: In highly myopic macular hole central retinal detachments, the ideal treatment is still under discussion. In our study, we analyzed anatomic and functional outcomes for eyes undergoing vitrectomy with primary silicone oil filling without central photocoagulation, using the oil as inductor and scaffold for glial closure of the causative macular hole.

Methods: Eleven patients with central macular hole detachments and myopia ranging from -10.

Assessment of central visual function in Stargardt's disease/fundus flavimaculatus with ultrahigh-resolution optical coherence tomography.

Purpose: To assess photoreceptor morphology in patients with Stargardt's disease and fundus flavimaculatus using ultrahigh-resolution optical coherence tomography (UHR-OCT) and correlate it with visual acuity (VA).

Methods: This was a prospective observational case series. Fourteen patients with Stargardt's disease (nine women, five men; average age, 39 years; range, 27-53) were examined.

Effect of anterior capsule polishing on fibrotic capsule opacification: three-year results.

Purpose: To evaluate the long-term effect of anterior capsule polishing on anterior capsule opacification (ACO) and peripheral fibrotic posterior capsule opacification (PCO).

Setting: Department of Ophthalmology, Medical University of Vienna, Vienna, Austria.

Methods: This randomized double-blind study comprised 104 eyes of 52 patients with bilateral age-related cataract.

Effect of a silicone intraocular lens with a sharp posterior optic edge on posterior capsule opacification.

Purpose: To compare the inhibiting effect on posterior capsule opacification (PCO) of a silicone intraocular lens (IOL) with a sharp posterior optic edge (ClariFlex OptiEdge, Advanced Medical Optics) and a silicone IOL with a round optic edge (PhacoFlex SI-40, Advanced Medical Optics).

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This prospective randomized patient- and examiner-masked study comprised 104 eyes of 52 patients with bilateral age-related cataract.

Laserinterferometric assessment of pilocarpine-induced movement of an accommodating intraocular lens: a randomized trial.

Purpose: To measure the axial movement of an accommodating intraocular lens (IOL) induced by ciliary muscle contraction after application of pilocarpine.

Design: Randomized, controlled, patient- and examiner-masked trial with intrapatient comparison.

Participants And Controls: One hundred ten eyes of 55 patients with age-related bilateral cataract.

Effect of optic edge design and haptic angulation on postoperative intraocular lens position change.

Purpose: To assess the effect of optic edge design and optic-haptic angulation of open-loop intraocular lenses (IOLs) on postoperative axial movement and the final position of the optic by measuring the anterior chamber depth (ACD) during the first postoperative year using partial coherence interferometry (PCI).

Setting: Department of Ophthalmology, Vienna General Hospital, Institute of Medical Physics, University of Vienna, Vienna, Austria.

Methods: In study 1, a 3-piece silicone IOL with nonangulated modified C-loop haptics (MicroSil, Dr.

Effect of haptic design on change in axial lens position after cataract surgery.

Purpose: To compare the postoperative changes in anterior chamber depth (ACD) between single-piece and multipiece AcrySof intraocular lenses (IOLs) (Alcon Laboratories, Inc.) and their effect on the postoperative refractive shift.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Postoperative change in effective lens position of a 3-piece acrylic intraocular lens.

Purpose: To study the change in postoperative position of an angulated, 3-piece, foldable acrylic intraocular lenses (IOLs) and evaluate the effect of a sharp posterior optic edge compared with that of a round optic edge on the change in postoperative anterior chamber depth (ACD).

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This randomized intraindividual-comparison study comprised 104 eyes of 52 patients with age-related cataract.

Influence of intraocular lens material on regeneratory posterior capsule opacification after neodymium:YAG laser capsulotomy.

Purpose: To evaluate the influence of a neodymium:YAG (Nd:YAG) laser capsulotomy on the morphology and development of regeneratory opacification of the remaining surrounding posterior capsule.

Setting: Department of Ophthalmology, Medical School, University of Vienna, Vienna, Austria.

Methods: Standardized digital retroillumination photographs were taken immediately before and after Nd:YAG laser capsulotomy and at 1 week, 6 months, and 1 to 3 years in 38 eyes of consecutive patients.

Enhanced visualization of macular pathology with the use of ultrahigh-resolution optical coherence tomography.

Objectives: To demonstrate a new generation of ophthalmic optical coherence tomography (OCT) technology with unprecedented axial resolution for enhanced imaging of intraretinal microstructures and to investigate its clinical feasibility to visualize intraretinal morphology of macular pathology.

Methods: A clinically viable ultrahigh-resolution ophthalmic OCT system was developed and used in clinical imaging for the first time. Fifty-six eyes of 40 selected patients with different macular diseases including macular hole, macular edema, age-related macular degeneration, central serous chorioretinopathy, epiretinal membranes, and detachment of pigment epithelium and sensory retina were included.

Short-term effect of dorzolamide hydrochloride on central corneal thickness in humans with cornea guttata.

Objective: To investigate the short-term effect of dorzolamide hydrochloride, a topical carbonic anhydrase inhibitor, on central corneal thickness in patients with cornea guttata.

Design And Methods: In this randomized, placebo-controlled, double-masked, 3-drug crossover study, 20 patients with cornea guttata (mean endothelial cell count, 1321 cells/mm2) and 8 healthy control subjects (mean endothelial cell count, 2483 cells/mm2) were included. Study medications included 2% dorzolamide hydrochloride (Trusopt 2% eye drops; Merck & Co Inc, Whitehouse Station, NJ), 0.

Corneal endothelial cell protection with a dispersive viscoelastic material and an irrigating solution during phacoemulsification: low-cost versus expensive combination.

Purpose: To evaluate the protective effect on corneal endothelial cells of a low-cost and an expensive combination of a dispersive viscoelastic material and an irrigating solution during phacoemulsification.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: This prospective randomized examiner- and patient-masked study comprised 90 eyes of 45 consecutive patients with age-related cataract in both eyes.

Reproducibility of standardized retroillumination photography for quantification of posterior capsule opacification.

Purpose: To determine the short-term reproducibility of standardized digital retroillumination images of regeneratory posterior capsule opacification (PCO) using the photographic setup at 1 institution.

Setting: Department of Ophthalmology, University of Vienna, Vienna, Austria.

Methods: In this prospective study, 60 retroillumination images of 30 eyes with varying degrees of PCO and different types of intraocular lenses were acquired with a standardized digital coaxial retroillumination system.

Refractive outcome of cataract surgery using partial coherence interferometry and ultrasound biometry: clinical feasibility study of a commercial prototype II.

Purpose: To evaluate the refractive outcome of cataract patients 3 months postoperatively using optical biometry obtained with a prototype version (axial length measurement, ALM, Carl Zeiss Jena) of the commercial partial coherence interferometry (PCI) instrument (IOLMaster, Carl Zeiss Jena).

Setting: Department of Ophthalmology, Vienna General Hospital, and Institute of Medical Physics, University of Vienna, Austria.

Methods: Forty-five patients with age-related cataract in both eyes were scheduled for bilateral cataract surgery.