CD94 natural killer cells potentiate pulmonary ischaemia-reperfusion injury.

Background: Pulmonary ischaemia-reperfusion injury (IRI) is a major contributor to poor lung transplant outcomes. We recently demonstrated a central role of airway-centred natural killer (NK) cells in mediating IRI; however, there are no existing effective therapies for directly targeting NK cells in humans.

Methods: We hypothesised that a depleting anti-CD94 monoclonal antibody (mAb) would provide therapeutic benefit in mouse and human models of IRI based on high levels of (CD94) transcripts in bronchoalveolar lavage samples from lung transplant patients.

Imprecise perception of hand position during early motor adaptation.

Localizing one's body parts is important for movement control and motor learning. Recent studies have shown that the precision with which people localize their hand places constraints on motor adaptation. Although these studies have assumed that hand localization remains equally precise across learning, we show that precision decreases rapidly during early motor learning.

Strategy-based motor learning decreases the post-movement β power.

Motor learning depends on the joint contribution of several processes including cognitive strategies aiming at goal achievement and prediction error-driven implicit adaptation. Understanding this functional interplay and its clinical implications requires insight into the individual learning processes, including at a neural level. Here, we set out to examine the impact of learning a cognitive strategy, over and above implicit adaptation, on the oscillatory post-movement β rebound (PMBR), which typically decreases in power following (visuo)motor perturbations.

[Pancytopenia, arthralgia and myeloneuropathy due to copper deficiency].

Background: Copper deficiency leads to hematologic disorders like pancytopenia. In addition, myeloneuropathy was described in a few cases reports.

Case Report: A 71-year-old woman was hospitalized because of increasing pancytopenia and ataxic gait, that resulted in a near-complete inability to walk without assistance.

Inscription of optical waveguides in crystalline silicon by mid-infrared femtosecond laser pulses.

For the first time to the authors' knowledge, optical waveguides have been inscribed in bulk crystalline silicon by ultrafast laser radiation. Femtosecond laser pulses of 40-nm spectral bandwidth, 1-kHz repetition rate, and 1.7-microJ on-target energy were applied at a mid-infrared wavelength of 2.

Discrete diffraction in two-dimensional arrays of coupled waveguides in silica.

The propagation of light in 5 x 5 and 7 x 7 cubic lattices of evanescently coupled waveguides is investigated for the first time, to the authors' knowledge. The results reveal ideal discrete diffraction and demonstrate the excellent quality of the waveguide arrays, which were manufactured in fused silica by femtosecond-laser-induced refractive-index modifications.

Optical properties of waveguides fabricated in fused silica by femtosecond laser pulses.

With tightly focused femtosecond laser pulses, waveguides are fabricated in fused silica. The guiding and attenuation properties of these waveguides at wavelengths of 514 nm and 1.5 microm are studied.