Two Colour Photoflow Chemistry for Macromolecular Design.

We report a photochemical flow setup that exploits λ-orthogonal reactions using two different colours of light (λ =350 nm and λ =410 nm) in sequential on-line irradiation steps. Critically, both photochemically reactive units (a visible-light reactive chalcone and a UV-activated photo-caged diene) are present in the reaction mixture. We demonstrate the power of two colour photoflow by the wavelength-selective end group modification of photo-caged polymer end groups and the subsequent polymer ring closure driven by a [2+2] cycloaddition.

Targeted and modular architectural polymers employing bioorthogonal chemistry for quantitative therapeutic delivery.

There remain several key challenges to existing therapeutic systems for cancer therapy, such as quantitatively determining the true, tissue-specific drug release profile , as well as reducing side-effects for an increased standard of care. Hence, it is crucial to engineer new materials that allow for a better understanding of the pharmacokinetic/pharmacodynamic behaviours of therapeutics. We have expanded on recent "click-to-release" bioorthogonal pro-drug activation of antibody-drug conjugates (ADCs) to develop a modular and controlled theranostic system for quantitatively assessing site-specific drug activation and deposition from a nanocarrier molecule, by employing defined chemistries.