Detecting Hexafluoroisopropanol Using Soft Chemical Ionization Mass Spectrometry and Analytical Applications to Exhaled Breath.

Here we explore the potential use of proton transfer reaction/selective reagent ion-time-of-flight-mass spectrometry (PTR/SRI-ToF-MS) to monitor hexafluoroisopropanol (HFIP) in breath. Investigations of the reagent ions HO, NO, and O are reported using (relative humidity (rH) ≈ 0%) and (rH ≈ 100%)) nitrogen gas containing traces of HFIP, i.e.