Publications by authors named "Matthias Tobias Warkotsch"
J Am Soc Nephrol
September 2020
Article Synopsis
- * In experiments using a nephrotoxic model of GN, AREG was found to be produced mainly by kidney resident cells, and its absence significantly reduced disease severity, indicating its pathogenic role in GN.
- * AREG promotes a pro-inflammatory response by stimulating myeloid cells and polarizing monocytes/macrophages towards a harmful M1 phenotype, suggesting that targeting the AREG/EGFR pathway could be a viable approach to treat acute GN.
