Identification of a discriminative metabolomic fingerprint of potential clinical relevance in saliva of patients with periodontitis using 1H nuclear magnetic resonance (NMR) spectroscopy.

Periodontitis is characterized by the loss of the supporting tissues of the teeth in an inflammatory-infectious context. The diagnosis relies on clinical and X-ray examination. Unfortunately, clinical signs of tissue destruction occur late in the disease progression.

Nuclear magnetic resonance spectroscopic analysis of salivary metabolome in sarcoidosis.

Background: Sarcoidosis is a systemic granulomatous disease of unknown cause which has diverse clinical impacts, ranging from benign to very severe, which may therefore require systemic treatment. Only a few tools are currently available to monitor management in these patients.

Objectives: As sarcoidosis is known to affect salivary glands, we hypothesized that analysis of saliva could reveal valuable biomarkers for disease management.