Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery.

The use of ultrasound has gained great interest for nucleic acids delivery. Ultrasound can reach deep tissues in non-invasive manner. The process of sonoporation is based on the use of low-frequency ultrasound combined with gas-filled microbubbles (MBs) allowing an improved delivery of molecules including nucleic acids in the insonified tissue.

Spatial variation of acoustic parameters in human skin: an in vitro study between 22 and 45 MHz.

This study of spatial variance of acoustic parameters was performed on eight nonfrozen samples of female abdominal skin (women 46.5 +/- 12.2 years old), obtained during plastic surgery.