Publications by authors named "Matthias Kuebler"
Article Synopsis
- Lung surfactant collectins, SP-A and SP-D, are proteins that play a crucial role in lung immunity by recognizing carbohydrates on pathogens and initiating immune responses.* -
- Research using microscale thermophoresis found that SP-A and SP-D bind strongly to glycosaminoglycans (GAGs) like hyaluronan and heparan sulfate, with binding that is not affected by calcium levels.* -
- The study indicates that these proteins not only target pathogens but also interact with the alveolar epithelial glycocalyx, which may influence its composition and structure, suggesting a broader role for SP-A and SP-D in lung health beyond just surfactant lipid interaction.*