Publications by Matthias Johannes John

Publications by authors named "Matthias Johannes John"

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Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.

Catherine Isabell Real Mengji Lu Jia Liu Xuan Huang Martin Trippler Matthias Johannes John

Sci Rep

April 2016

The hepatitis B virus (HBV) has been described as stealth virus subverting immune responses initially upon infection. Impaired toll-like receptor signaling by the HBV surface antigen (HBsAg) attenuates immune responses to facilitate chronic infection. This implies that HBV replication may trigger host innate immune responses in the absence of HBsAg.

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- Matthias Johannes John's research primarily focuses on the interaction between hepatitis B virus (HBV) and the host immune system, particularly how HBV evades immune detection and response mechanisms.
- His 2016 study published in "Sci Rep" reveals that HBV genome replication activates toll-like receptor 3 (TLR3)-dependent interferon responses even when the hepatitis B surface antigen (HBsAg) is absent, suggesting a complex role of HBV in modulating immune responses.
- The findings highlight the potential for targeting TLR3 pathways as a therapeutic approach to bolstering immune responses against HBV, which may lead to improved outcomes in chronic HBV infections.

Publications by authors named "Matthias Johannes John"

Hepatitis B virus genome replication triggers toll-like receptor 3-dependent interferon responses in the absence of hepatitis B surface antigen.

Synopsis of recent research by authors named "Matthias Johannes John"