Efficacy of Duloxetine in Chronic Low Back Pain with a Neuropathic Component: A Randomized, Double-blind, Placebo-controlled Crossover Trial.

Background: Among patients with chronic low back pain (CLBP), approximately 37% show signs of a neuropathic pain component (radicular pain). Treatment of this condition remains challenging. Therefore, the current study aimed to investigate the efficacy of duloxetine in the treatment of CLBP patients with neuropathic leg pain.

Age-dependent changes of the periodontal ligament in rats.

Even after the end of the natural tooth eruption, there is a continuous renewal of the periodontal collagenous fiber system, depending on functional demands. The aim of this study was to analyse the age-dependent changes and regional differences of the collagen renewal rate of the periodontal ligament in healthy rats. The study was performed by autoradiography of the molars of rats aged 1, 8, and 18 months, where collagen was labelled by intravenously applied 3H-proline.

Lymph drainage in the human dental pulp.

We investigated which structural components are responsible for maintaining interstitial fluid equilibrium in the pulpal tissue, for which the existence of an effective lymph drainage is postulated. There have been only a small number of investigations on pulpal lymph tissue. Therefore, we decided to perform a detailed structural analysis.

Intrathecal temperature is closely reflected by the aortic, but not by the rectal, temperature in a rabbit model of spinal cord ischemia.

Experimental ischemic lesions in the lumbar spinal cord of the rabbit can be induced by inflating the balloon of a Swan-Ganz catheter in the abdominal aorta. The intrathecal temperature is significantly better reflected by the temperature from the thermistor of the catheter than by the rectal temperature.