Publications by authors named "Matthias Heikenwalder"
Article Synopsis
- Monocytes and macrophages promote cancer progression and metastasis, particularly in the lungs, through mechanisms involving specific chemokines like CCR2 and CCR1.
- Research using mice deficient in Ccr1 and Ccr2 indicated that without these receptors, monocyte recruitment towards the primary chemokine Ccl2 was impaired, leading to reduced lung metastasis in certain tumor types (MC38 and LLC1).
- The study suggests that while CCR2 handles monocyte release from bone marrow, CCR1 is crucial for their accumulation at tumor sites, indicating distinct roles for these chemokine receptors in cancer metastasis.
Platelet activation plays a critical role in thrombosis. Inhibition of platelet activation is a cornerstone in treatment of acute organ ischemia. Platelet ACKR3 surface expression is independently associated with all-cause mortality in CAD patients.
View Article and Find Full Text PDFHelicobacter pylori infection induces a number of pro-inflammatory signaling pathways contributing to gastric inflammation and carcinogenesis. Among those, NF-κB signaling plays a pivotal role during infection and malignant transformation of the gastric epithelium. However, deficiency of the adaptor molecule myeloid differentiation primary response 88 (MyD88), which signals through NF-κB, led to an accelerated development of gastric pathology upon H.
View Article and Find Full Text PDFAdaptive immune responses are initiated when T cells encounter antigen on dendritic cells (DC) in T zones of secondary lymphoid organs. T zones contain a 3-dimensional scaffold of fibroblastic reticular cells (FRC) but currently it is unclear how FRC influence T cell activation. Here we report that FRC lines and ex vivo FRC inhibit T cell proliferation but not differentiation.
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