Publications by authors named "Matthias HarlaSS"
Importance: Prior studies have shown that the benefits, harms, and costs of colorectal cancer (CRC) screening at older ages are associated with a patient's sex, health, and screening history. However, these studies were hypothetical exercises and not directly informed by data on CRC risk.
Objective: To identify the optimal stopping ages for CRC screening by sex, comorbidity, and screening history from a cost-effectiveness perspective.
Article Synopsis
- The Affordable Care Act removed out-of-pocket costs for recommended preventive services, but a recent court ruling may reinstate these costs for over 150 million Americans, particularly affecting colorectal cancer screenings.
- If the court's decision stands, it could specifically impact screening for colorectal cancer in people aged 45-49 and polyp removals during colonoscopies for all ages.
- A simulation showed that a decrease in screening participation by 8% could lead to a significant rise in colorectal cancer cases and deaths, while potentially reducing costs in the short term due to increased cost-sharing, but higher participation loss could result in greater overall healthcare costs.
The aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in colorectal cancer (CRC) outcomes due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation.
View Article and Find Full Text PDFThe aftermath of the initial phase of the COVID-19 pandemic may contribute to the widening of disparities in access to colorectal cancer (CRC) screening due to differential disruptions to CRC screening. This comparative microsimulation analysis uses two CISNET CRC models to simulate the impact of ongoing screening disruptions induced by the COVID-19 pandemic on long-term CRC outcomes. We evaluate three channels through which screening was disrupted: delays in screening, regimen switching, and screening discontinuation.
View Article and Find Full Text PDFBackground: Patients with skin cancer increasingly watch online videos to acquire disease-related information. Until now, no scientific evaluation of the quality of videos available for German-speaking patients with basal cell carcinoma (BCC) has been performed.
Objective: In this study, we aimed to identify and evaluate videos about BCC provided on YouTube.
Multiple interventions are available for the treatment of actinic keratosis (AK) showing high efficacy in pivotal trials. However, data from post-marketing surveillance studies have received little attention until now. Here, we systematically investigate interventions for AK from post-marketing surveillance trials as a proxy for real-world efficacy and tolerability.
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