Publications by authors named "Matthias Golla"
Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell fate mapping with a thymidine kinase (sr39tk) reporter gene for cell detection by positron emission tomography (PET).
View Article and Find Full Text PDFAtaxin-3, the disease protein in Machado-Joseph disease, is known to be proteolytically modified by various enzymes including two major families of proteases, caspases and calpains. This processing results in the generation of toxic fragments of the polyglutamine-expanded protein. Although various approaches were undertaken to identify cleavage sites within ataxin-3 and to evaluate the impact of fragments on the molecular pathogenesis of Machado-Joseph disease, calpain-mediated cleavage of the disease protein and the localization of cleavage sites remained unclear.
View Article and Find Full Text PDFArticle Synopsis
- Spinocerebellar ataxia type 3 (SCA3) is a genetic neurodegenerative disorder caused by a CAG repeat expansion in the ATXN3 gene, which disrupts the normal function of ataxin-3 protein.
- Research on the antiglutamatergic drug riluzole as a potential treatment showed that, while it reduced soluble ataxin-3 levels, it did not improve motor skills or overall behavior in SCA3 mice.
- Long-term riluzole treatment may worsen symptoms by increasing glutamate release and damaging Purkinje cells, indicating caution in its use for SCA3 patients.
This prospective study was conducted to demonstrate that the matte-finish Basis CL cemented endoprosthetic stem delivers good qualitative results after 10 years. Between January and December 1999, 205 consecutive hips (201 patients; 74.5 ± 6.
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