Elementary immunology: Na as a regulator of immunity.

The skin can serve as an interstitial Na reservoir. Local tissue Na accumulation increases with age, inflammation and infection. This increased local Na availability favors pro-inflammatory immune cell function and dampens their anti-inflammatory capacity.

Metabolic-energy-dependent movement of PML bodies within the mammalian cell nucleus.

Promyelocytic leukaemia (PML) nuclear bodies are present in most mammalian cell nuclei. PML bodies are disrupted by PML retinoic acid receptor alpha (RAR alpha) oncoproteins in acute promyelocytic leukaemia. These bodies contain numerous proteins, including Sp100, SUMO-1, HAUSP(USP7), CBP and BLM, and they have been implicated in aspects of transcriptional regulation or as nuclear storage depots.