Publications by authors named "Matthias D H Zink"
The Glasgow-Pittsburgh cerebral performance categories (GP-CPC) and the Glasgow Outcome Score (GOS) have been used to categorize patients according to their neurological outcome for prognostic predictors in patients after cardiac arrest (CA). We postulated that inclusion of deaths without knowing the cerebral status into the group of patients with poor outcome after CA using the GP-CPC and GOS will lead to dilution of the prognostic power of the investigated biochemical marker. The present study was conducted to verify this issue by employing a modified outcome score, which we termed as Modified Glasgow Outcome Score (MGOS).
View Article and Find Full Text PDFMechanical stretch has been shown to increase vascular endothelial growth factor (VEGF) expression in cultured myocytes. Sympathetic neurons (SN) also possess the ability to express and secrete VEGF, which is mediated by the NGF/TrkA signaling pathway. Recently, we demonstrated that SN respond to stretch with an upregulation of nerve growth factor (NGF) and ciliary neurotrophic factor (CNTF).
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the effects of high-frequency electric stimulation (HFES) on cardiac neurons to control ventricular rate during atrial fibrillation in dogs, showing a reduction in intrinsic ventricular rate over several months when HFES was paused.
- - Results indicated that chronic HFES led to increased neuronal cell size and elevated levels of growth factors such as β-nerve growth factor (NGF) and neurotrophin (NT)-3, while also improving neuronal function through the upregulation of acetylcholine.
- - These findings suggest that HFES enhances parasympathetic function in the heart, potentially paving the way for improved techniques to manage cardiac conditions.