Apheresis for chimeric antigen receptor T-cell production in adult lymphoma patients.

Background: To date, in-depth analysis of leukapheresis products as starting material for CAR T-cell manufacturing, specifically Tisagenlecleucel production, are scarce. In this study, we report on lymphapheresis data for production of Tisagenlecleucel for elderly and pretreated lymphoma patients.

Study Design And Methods: Spectra Optia from Terumo BCT, Lakewood, CO, was employed for apheresis using the cMNC program.