Draft genome of a human-derived that caused spontaneous disseminated infection in a mouse.

We present the draft genome of a novel human-derived strain isolated from a healthy control human microbiota that, when put into a mouse, spontaneously disseminated from the gut to the kidneys.

Aromatic ointments for the common cold: what does the science say?

Background: Upper respiratory tract infections occur with an annual incidence of 17.2 billion cases globally. The negative impact that symptoms have on sleep is thought to slow the recovery process.

Little time, lasting impact: Bereaved caregiver perceptions of legacy in perinatal and infant loss.

Background: Legacy interventions are standard in most children's hospitals, but little is known about how bereaved parents understand and describe the concept of legacy that these interventions are designed to Address. The aim of this qualitative study was to understand the legacy experiences and perceptions of parents who have experienced perinatal or early infant (less than three months of age) loss.

Methods: Grounded in constructionist epistemology and phenomenological qualitative traditions, ten bereaved parents completed an in-depth phenomenological interview regarding their perceptions of and experiences with the legacy of their deceased child.

Transfer of hepatocellular microRNA regulates cytochrome P450 2E1 in renal tubular cells.

Background: Extracellular microRNAs enter kidney cells and modify gene expression. We used a Dicer-hepatocyte-specific microRNA conditional-knock-out (Dicer-CKO) mouse to investigate microRNA transfer from liver to kidney.

Methods: Dicer mice were treated with a Cre recombinase-expressing adenovirus (AAV8) to selectively inhibit hepatocyte microRNA production (Dicer-CKO).

Absence of MyD88 from Skeletal Muscle Protects Female Mice from Inactivity-Induced Adiposity and Insulin Resistance.

Objective: Inactivity and inflammation are linked to obesity and insulin resistance. It was hypothesized that MyD88 (mediates inflammation) knockout from muscle (MusMyD88 ) would prevent, whereas miR146a (MyD88 inhibitor) would exacerbate, inactivity-induced metabolic disturbances.

Methods: Cre-control, MusMyD88 , and miR146a mice were given running wheels for 5 weeks to model an active phenotype.

Ground water rights, spatial variation, and transboundary conflicts.

The goal for any property rights system is to achieve equity, efficiency, and certainty. Trying to achieve these goals for ground water is difficult because a ground water right is not exclusive. To make matters more complicated, ground water is often under the jurisdiction of more than one political unit.

Switching of pseudorotaxanes and catenanes incorporating a tetrathiafulvalene unit by redox and chemical inputs.

An acyclic polyether 1a, incorporating a central tetrathiafulvalene (TTF) electron donor unit and two 4-tert-butylphenoxy groups at its termini, has been synthesized. Two macrocyclic polyethers containing two different electron donors, namely a TTF unit with, in one case, a 1,4-dioxybenzene ring (2a), and, in the other case (2b), a 1,5-dioxynaphthalene ring system, have also been synthesized. These two macrocyclic polyethers have been mechanically interlocked in kinetically controlled template-directed syntheses with cyclobis(paraquat-p-phenylene) cyclophane (3(4+)) to afford the [2]catenanes 2a/3(4+) and 2b/3(4+), respectively.

Nutrition education at the point of purchase: the foods for health project evaluated.

Foods for Health, a nutrition education and research program sponsored by the National Heart, Lung, and Blood Institute and Giant Food, Inc., was designed to demonstrate the feasibility of cardiovascular nutrition education at the point of purchase, specifically, in the supermarket. To evaluate the program's effectiveness, measures of consumer awareness, knowledge, and food purchases were determined before, during, and after the campaign.

Left atrial myxoma presenting as a systemic vasculitis.

Left atrial myxoma has often stimulated systemic vasculitis or a connective tissue disease, but the diagnosis is usually suggested by cardiac symptoms or signs. The present case report is both unusual and instructive in that the patient presented with a painless left foot drop followed by digital vasculitis. Laboratory findings included depressed total hemolytic complement and elevated anti-double-stranded DNA.

Incidence of arrhythmias induced by isometric and dynamic exercise.

The incidence of arrhythmias during isometric sustained handgrip exercise and during dynamic graded bicycle exercise was compared in a group of 45 patients with various forms of heart disease on no antiarrhythmic therapy. Atrial arrhythmias were equally common during handgrip and bicycle exercise but ventricular arrhythmias were more frequent during handgrip exercise. Of the 45 patients, 38 per cent developed ventricular arrhythmias during isometric exercise, with ventricular tachycardia occurring in 15 per cent.