Publications by authors named "Matthew Withiam-Leitch"

Article Synopsis
  • - Identifying phenotypic subtypes of chronic kidney disease (CKD) is crucial for better risk assessment and targeted therapies, given the disease's varied progression rates among patients.
  • - The study utilizes electronic health records (EHR) to extract severity profiles of CKD, employing a probabilistic model to analyze patient data and determine distinct disease subtypes.
  • - Results show clinically relevant disease subtypes and associated health markers, suggesting potential for using these findings as risk predictors in future research.
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Objectives: The positive predictive value (PPV) of a single assessment of estimated glomerular filtration rate (eGFR) in the diagnosis of chronic kidney disease (CKD) is not known. Our objective was to determine the PPV of a single assessment of eGFR among adults with at least one eGFR <60 mL/min in their lifetime, using the Distributed Area Research and Therapeutics Network CKD natural history dataset.

Methods: In all, 47,104 adults who were cared for by 113 practices in the United States were included.

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Background: Inaccurate use of International Classification of Diseases, Ninth Revision (ICD-9), codes obfuscates registries used for research, resulting in unreliable data and inaccurate measurement of outcomes, and it may contribute to mismanagement of patients. Thus it is important to understand the prevalence of ICD-9 code misuse. We chose chronic kidney disease (CKD) as a condition of interest after several patients recruited for a previous study indicated they did not have the disease, despite the presence of the ICD-9 code (585.

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There is evidence that early and frequent encounters with people with disabilities can improve medical students' knowledge, skills, and attitudes about disability. As part of a 4-year integrated curriculum in caring for patients with disabilities, third-year medical students (n = 144) in a Family Medicine clerkship participated in a day-long precepted clinical experience at a medical facility serving people with disabilities, predominantly developmental disabilities, where they met patients and worked with clinicians. At the conclusion of the program, students completed a reflective survey about their experience.

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Objective: Negative healthcare provider attitudes toward patients with physical disabilities may challenge the delivery of quality care to patients. The objective of this study was to systematically review published studies examining the attitudes of healthcare students and professionals toward patients with physical disabilities.

Design: In October 2011, we searched four electronic databases using the OVID platform.

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Objective: To evaluate the usefulness of pre-operative serum CA-125 in the management of women diagnosed with uterine papillary serous carcinoma (UPSC). We hypothesized that elevated pre-operative levels of serum CA-125 correlate with higher disease stage and poorer prognosis.

Methods: Patients diagnosed with UPSC and managed in our institution were identified over a period of 10 years, 1995 to 2005.

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Background: The Accreditation Council on Graduate Medical Education (ACGME) Outcomes Project has endorsed the in-training examination (ITE) as an example of a multiple-choice question examination that is a valid measure of a resident's attainment of medical knowledge. An outcome measure for performance on the ITE would be the subsequent performance on the board certification examination. However, there are few reports that attempt to correlate a resident's performance on the ITE to subsequent performance on the board certification examination.

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Background: The purpose of this case report is to describe the failure of standard diagnostic work up in the presence of an advanced stage endometrial cancer and briefly review the literature about the efficacy of the currently utilized diagnostic tools in the evaluation of women with postmenopausal bleeding (PMB).

Case: A 71-year-old normal weight lady presented with an unprovoked PMB. Initial evaluation consisted of pelvic ultrasound followed by office hysteroscopy and directed endometrial biopsy.

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Background: The aim of this paper is to report a case of synchronous ovarian malignancy in a very young patient with early endometrial cancer who desired fertility-sparing management.

Case: Twenty one-year-old patient presented with an apparent early stage endometrial cancer and desiring conservative management. After failure of conservative management for 3 years, surgery was performed.

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Background: In a trend similar to continuous electronic fetal monitoring, many hospitals are incorporating central fetal monitoring into labor and delivery suites. The objective of this study was to investigate whether the use of central fetal monitoring had an effect on neonatal outcomes or cesarean section rate.

Methods: This retrospective study involved patient data from deliveries occurring at Women and Children's Hospital of Buffalo, Buffalo, New York, between the years 2000 and 2003.

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Background: To date, there is no published data showing a correlation between the National Residency Matching Program Ranklist position and performance in residency.

Purpose: The background was to assess whether a residency applicant selection process is able to predict the subsequent performance of candidates during residency.

Methods: Over a period of 3 academic years, resident candidates were invited to a structured interview process.

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Objective: To assess whether male obstetric and gynecologic residents experience gender bias in training for vaginal deliveries.

Study Design: We compared male and female resident training experiences in vaginal deliveries in a community hospital. Three analyses were performed: (1) total number of deliveries performed by male and female residents, (2) percentage of deliveries that male and female residents performed with female attendings, and (3) percentage of attending deliveries performed by male residents.

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Mastalgia affects up to two-thirds of women at some time during their reproductive lives. It is usually benign, but thefear of underlying breast cancer is why many women present for evaluation. Mastalgia can be associated with premenstrual syndrome, fibrocystic breast disease, psychologic disturbance and, rarely, breast cancer.

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Background: Primary primitive neuroectodermal (pPNET) tumors rarely occur in adults, and they very rarely present as primary tumors of the uterus. Only 12 reported cases of pPNET of the uterus have been published in the English literature. We report two additional cases treated at the Roswell Park Cancer Institute, Buffalo, NY, between 1999 and 2002.

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