A Novel Animal Model for Studying Depression Featuring the Induction of the Unfolded Protein Response in Hippocampus.

Depression is the leading cause of disability worldwide with global distribution of 322 million people suffering from the disease. While much is understood about depression, the underlying pathophysiology is yet to be fully characterized. Recently, the unfolded protein response (UPR) has been shown to be involved in regulating key aspects like inflammation, cell death, and behavioral depression.