Publications by authors named "Matthew T Whitney"
Diagnostic testing for Zika virus (ZIKV) or dengue virus (DENV) infection can be accomplished by a nucleic acid detection method; however, a negative result does not exclude infection due to the low virus titer during infection depending on the timing of sample collection. Therefore, a ZIKV- or DENV-specific serological assay is essential for the accurate diagnosis of patients and to mitigate potential severe health outcomes. A retrospective study design with dual approaches of collecting human serum samples for testing was developed.
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- - Dengue fever, caused by four serotypes of the dengue virus, is the leading cause of arboviral diseases globally, and virus-like particles (VLPs) derived from the virus have potential as vaccine candidates.
- - Researchers engineered mature dengue VLPs (mD2VLP) from serotype-2, which exhibited a consistent size of approximately 31 nm and a specific icosahedral symmetry, revealing new neutralizing epitopes on the E-protein.
- - Mice vaccinated with these mD2VLPs produced strong cross-reactive neutralizing antibodies and were fully protected against all four dengue serotypes, indicating a promising direction for future dengue vaccine development.