Unveiling the Promise: Navigating Clinical Trials 1978-2024 for PDAC.

Despite many decades of research, pancreatic ductal adenocarcinoma (PDAC) remains one of the most difficult cancers to diagnose and treat effectively. Although there have been improvements in the 5-year overall survival rate, it is still very low at 12.5%.

Intermolecular [5 + 1]-Cycloaddition between Vinyl Diazo Compounds and -Butyl Nitrite to 1,2,3-Triazine 1-Oxides and Their Further Transformation to Isoxazoles.

1,2,3-Triazine 1-oxides are formed by nitrosyl addition from -butyl nitrite to the vinylogous position of vinyl diazo compounds. This transformation, which is a formal intermolecular [5 + 1] cycloaddition, occurs under mild conditions, with high functional group tolerance and regioselectivity, and can be employed for late-stage functionalization. Upon heating at refluxing chlorobenzene temperature, these triazine--oxides undergo dinitrogen extrusion to form isoxazoles in very high yields.