Publications by authors named "Matthew T Mattoon"
Article Synopsis
- Our skin acts as a protective shield, primarily through the interfollicular epidermis, but the role of hair follicles in this process is not fully understood.
- A study using a genetic tool to disable the Abca12 gene, linked to a severe skin condition, uncovered four ways hair follicles influence skin barrier function.
- These include the upper hair follicle forming a barrier, triggering epidermal responses when disrupted, affecting sebum release, and causing hair follicle cells to migrate into the epidermis; blocking IL-17a helped ease some symptoms.
Article Synopsis
- Hair follicles play a significant role in skin barrier function, which is crucial for protection against environmental factors.
- By using a genetic tool to study the deletion of a key gene linked to a severe skin condition, researchers discovered four specific ways hair follicles influence barrier function.
- The study also highlights the potential of targeting Il17a to improve certain skin disease symptoms related to barrier dysfunction.
ProSAAS is one of the most abundant proteins in the brain and is processed into several smaller peptides. One of which, BigLEN, is an endogenous ligand for the G protein-coupled receptor, GPR171. Recent work in rodent models has shown that a small-molecule ligand for GPR171, MS15203, increases morphine antinociception and is effective in lessening chronic pain.
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