Publications by authors named "Matthew T Bird"
Article Synopsis
- Antimicrobial-resistance (AMR) genes can be exchanged between bacteria through horizontal gene transfer (HGT), involving various genetic elements like plasmids and bacteriophages, but the role of bacteriophages in AMR is not yet fully understood.
- Researchers identified a new ~98 kbp circular P1-bacteriophage-like plasmid called ph681355 from a clinical Salmonella Typhi isolate, which includes specific plasmid replicons and mobile elements, marking the first report of such a phage-plasmid in this bacteria.
- The study indicates that long-read sequencing can reveal the complex structure of AMR genes in bacteria, suggesting that bacteriophage-mediated genetic transfer may be more common and contribute
Increasing levels of antimicrobial resistance (AMR) have been documented in causing travellers' diarrhoea, particularly to the third-generation cephalosporins. Diarrhoeagenic (DEC) can act as a reservoir for the exchange of AMR genes between bacteria residing in the human gut, enabling them to survive and flourish through the selective pressures of antibiotic treatments. Using Oxford Nanopore Technology (ONT), we sequenced eight isolates of DEC from four patients' specimens who had all recently returned to the United Kingdome from Pakistan.
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