Deacetylated Sialic Acid Sensitizes Lung and Colon Cancers to Novel Cucurbitacin-Inspired Estrone Epidermal Growth Factor Receptor (EGFR) Inhibitor Analogs.

Cancers utilize sugar residues such as sialic acids (Sia) to improve their ability to survive. Sia presents a variety of functional group alterations, including O-acetylation on the C6 hydroxylated tail. Previously, sialylation has been reported to suppress EGFR activation and increase cancer cell sensitivity to Tyrosine Kinase Inhibitors (TKIs).

Using GIS in a first national mapping of functional disability among older American Indians and Alaska Natives from the 2000 census.

Background: Geographical information systems (GIS) have been used mainly in understanding infectious diseases and environmental threats in health research. Here, GIS was used to examine patterns of functional disability as one impact of chronic disease in American Indians and Alaska Natives. The study purpose was to create the first national mapping of functional disability for AIANs using the 2000 U.

GIS(c): a scientific framework and methodological tool for nursing research.

The purpose of this article was to bring to nursing science a theoretical framework and technology that can transport with it new ways of knowing by exploiting microperspectives and macroperspectives, both from "within the map" and globally. Nursing continues to find its voice, but it also must lend its voice to the forming of Geographic Information Systems and Science in a pan-disciplinary partnership with geography, cartography, sociology, public health, and information technology. It is proposed that nursing take advantage of the latest databases that hold "person" information and layer these over geographical maps holding "environment" and "health" information as a new way of seeing and applying the metaparadigms of nursing.