Publications by authors named "Matthew Salaciak"

Despite the rapidly emerging evidence on the contributions of physical activity to improving cancer-related health outcomes, adherence to physical activity among young adults with lymphoma remains suboptimal. Guided by self-determination theory (SDT), the intervention (a 12-week individualized exercise program with bi-weekly kinesiologist support and an activity tracker) aimed to foster autonomous motivation toward physical activity. This pilot randomized controlled trial aimed to evaluate the feasibility, acceptability, and preliminary effects of .

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Article Synopsis
  • Diffuse large B-cell lymphoma (DLBCL) relapses in about 40% of patients after initial treatment, with mutations in STAT6 linked to these relapses and indicating a role in resistance to therapy.
  • Research shows that STAT6 mutations help DLBCL cells survive by reprogramming their surrounding environment and enhancing cell signaling, particularly after IL-4 stimulation.
  • The study identifies the increased expression of survival-related genes, including CCL17, which recruits helper T-cells to the tumor area, suggesting that STAT6 mutations change both the behavior of the cancer cells and the immune landscape in DLBCL.
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Background And Objective: Treatments of lymphoma can lead to reduced physical functioning, cancer-related fatigue, depression, anxiety, and insomnia. These side effects can negatively impact the cancer survivor's quality of life. Mounting evidence indicates that physical activities are highly therapeutic in mitigating the short- and long-term side effects of cancer treatments.

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Patients with B-non-Hodgkin lymphoma (NHL) are at increased risk of morbidity and mortality from SARS-CoV-2. We investigated the relationship between B cell cytopenia and the SARS-CoV-2 vaccine response in B-NHL patients. We measured anti-RBD antibodies and the lymphocyte immunophenotype in 19 controls, 22 lymphoma patients on observation (cohort 1) and 55 lymphoma patients receiving their vaccines post B-cell depleting therapy (cohort 2).

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