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Publications by authors named "Matthew S Squires"

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Synopsis of recent research by authors named "Matthew S Squires"

  • Matthew S Squires' research primarily focuses on the development and characterization of small-molecule inhibitors targeting specific kinases involved in various hematological malignancies and myeloproliferative disorders.
  • His studies highlight the efficacy of multi-targeted kinase inhibitors like AT9283 and AT7519 in treating imatinib-resistant BCR-ABL-positive leukemic cells, as well as their potential applications in myeloproliferative neoplasms due to their effects on key signaling pathways like JAK2 and cyclin-dependent kinases.
  • Additionally, Squires investigates the mechanistic impact of natural compounds such as curcumin on apoptosis in breast cancer cells, illustrating the interplay between various signaling pathways and therapeutic interventions.

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