Genetics, Pregnancy, and Aortic Degeneration.

We present a case of familial thoracic aortic aneurysm and dissection (FTAAD) in a pregnant female. FTAAD is an inherited, nonsyndromic aortopathy resulting from several genetic mutations critical to aortic wall integrity have been identified. One such mutation is the myosin heavy chain gene (MYH11) which is responsible for 1-2% of all FTAAD cases.

Safety and efficacy of prothrombin complex concentrates for the treatment of coagulopathy after cardiac surgery.

Objective: Coagulopathy is an important cause of bleeding after complex cardiac surgery. The conventional treatment for coagulopathy is transfusion, which is associated with adverse outcomes. We report our initial experience with the prothrombin complex concentrate FEIBA (factor VIII inhibitor bypassing activity) for the rescue treatment of coagulopathy and life-threatening bleeding after cardiac surgery.

Combined heart-kidney transplant improves post-transplant survival compared with isolated heart transplant in recipients with reduced glomerular filtration rate: Analysis of 593 combined heart-kidney transplants from the United Network Organ Sharing Database.

Objective: Criteria for simultaneous heart-kidney transplant (HKTx) recipients are unclear. We characterized the evolution of combined HKTx in the United States over time compared with isolated heart transplantation (HTx) and determined factors maximizing post-transplant survival. We focused on whether a threshold estimated glomerular filtration rate (eGFR) could be identified that justified combined transplantation.

Right ventricular outflow tract cannulation for right ventricular assist device implantation.

A need persists for implantable devices that provide support for the failing right ventricle. The anatomy of the right ventricle presents unique challenges at the time of right ventricular assist device implant. We describe a technique for right ventricular outflow tract cannulation that minimizes the risk of right ventricular assist device inflow cannula obstruction and right ventricular compression.

Left atrial plication for heart transplantation in patients with giant left atrium.

Giant left atrium occasionally occurs in patients undergoing heart transplantation and causes a technical challenge for the surgeon because of the substantial discrepancy in size between the left atrial cuffs of the recipient and donor. We describe a left atrial plication technique that substantially reduces this discrepancy and allows for a standard left atrial anastomosis to be performed without any other modifications in technique.

Mechanical circulatory support pathways that maximize post-heart transplant survival.

Background: Heart transplant (HTx) recipients reach transplantation through increasing numbers of support pathways, including transition from one pathway to another. Outcomes of patients successfully bridged with various support pathways are unknown. We sought to identify mechanical circulatory support pathways that maximize survival after HTx.

Impact of single-ventricle physiology on death after heart transplantation in adults with congenital heart disease.

Background: Prevalence of univentricular (1V) anatomy over time and whether 1V anatomy is associated with early death after heart transplant (HTx) among recipients with adult congenital heart disease (ACHD) is unknown. We investigated changes in case-mix over time, 1V vs biventricular (2V) status, and the effect of 1V anatomy on death after HTx among ACHD recipients.

Methods: The Nationwide Inpatient Sample (NIS) was used to identify ACHD HTx recipients in the United States aged 14 years or older from 1993 to 2007, divided into era 1 (1993 to 2000) and era 2 (2001 to 2007).

Patient-specific insulin-resistance-guided infusion improves glycemic control in cardiac surgery.

Background: Maintenance of appropriate capillary blood glucose in cardiovascular surgery patients has been associated with improved outcomes, including lower mortality. Interpatient variability in insulin resistance can make management difficult, leading to unexpected episodes of hypoglycemia and hyperglycemia. To improve postoperative glucose control at our institution, a patient-specific insulin-resistance-guided (IRG) protocol was developed.

Favorable early outcomes for patients with extended indications for thoracic endografting.

Background: Endografts originally designed and approved for the treatment of thoracic aortic aneurysms have rapidly been adopted for nonapproved use in the treatment of disorders of the thoracic aorta, including aortic transection, dissection, pseudoaneurysms, and thoracoabdominal aneurysms. The purpose of this study was to evaluate the early outcomes of patients treated with thoracic endografts for nonapproved indications at our institution.

Methods: The medical records of patients undergoing thoracic endografting at our institution from August 2005 until March 2008 were reviewed.

Improved quality and cost-effectiveness of coronary artery bypass grafting in the United States from 1988 to 2005.

Objective: This study was undertaken to assess the impact of increasing patient complexity and health care cost on coronary artery bypass grafting quality and cost-effectiveness in the United States over an 18-year period.

Methods: A retrospective study was carried out utilizing the Nationwide Inpatient Sample to track the characteristics and outcomes of 5,549,700 patients having isolated coronary artery bypass grafting in the United States from 1988 to 2005. Expected mortality, risk-adjusted mortality, and hospital charges were tracked over this period.

Traumatic thoracic aortic transection in small-diameter aortas: percutaneous endograft repair.

The authors describe percutaneous repair of traumatic aortic transection in small-caliber aortas by using iliac extender stent-grafts in three patients (two female and one male patient; average age, 29.3 years). The average aortic diameters were 18.

Treatment of endocarditis: a decade of experience.

Background: Endocarditis represents a small proportion of cardiovascular disease but is associated with high mortality. Previous studies have reported a range of outcomes, and determinants of mortality remain poorly defined.

Methods: The goal of this retrospective study was to identify independent variables for early and late mortality in 364 consecutive patients with endocarditis over a 10-year period.

Becker's muscular dystrophy and orthotopic heart transplantation: perioperative considerations.

Patients with Becker's and Duchenne's muscular dystrophy occasionally have myocardial involvement leading to end-stage heart failure. Heart transplantation is established as an effective therapy. Achieving successful outcomes in this challenging group requires special consideration during the perioperative period to limit preoperative deconditioning, minimize anesthesia complications, and rapidly institute rehabilitation with appropriate precautions.

Spontaneous rupture of the thoracic aorta.

Spontaneous rupture of the aorta without previous history of trauma, hypertension, or apparent aortic pathology is exceedingly rare. Delayed or nonoperative repair of this condition is usually lethal. Survival after spontaneous mid arch aortic rupture requires a high index of suspicion, rapid and appropriate diagnostic tests, and early operative repair.

Leiomyomatosis metastatic to the tricuspid valve complicated by pelvic hemorrhage.

Metastatic leiomyomatosis is a rare but potentially life-threatening tumor of smooth muscle cells. Leiomyomas originate predominantly in the uterus and can spread to the lung and, rarely, the heart. We present a case of a 36-year-old woman with known pelvic leiomyomatosis with metastasis to the tricuspid valve.

Crush injury and rhabdomyolysis.

Crush injuries resulting in traumatic rhabdomyolysis are an important cause of acute renal failure. Ischemia reperfusion is the main mechanism of muscle injury. Intravascular volume depletion and renal hypoperfusion, combined with myoglobinuria, result in renal dysfunction.