Developmentally regulated H2Av buffering via dynamic sequestration to lipid droplets in embryos.

Regulating nuclear histone balance is essential for survival, yet in early embryos many regulatory strategies employed in somatic cells are unavailable. Previous work had suggested that lipid droplets (LDs) buffer nuclear accumulation of the histone variant H2Av. Here, we elucidate the buffering mechanism and demonstrate that it is developmentally controlled.