ATF3 Repression of BCL-X Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types.

Histone deacetylase inhibitors (HDACi) are epigenome-targeting small molecules approved for the treatment of cutaneous T-cell lymphoma and multiple myeloma. They have also demonstrated clinical activity in acute myelogenous leukemia, non-small cell lung cancer, and estrogen receptor-positive breast cancer, and trials are underway assessing their activity in combination regimens including immunotherapy. However, there is currently no clear strategy to reliably predict HDACi sensitivity.

Activating transcription factor 3 contributes to Toll-like receptor-mediated macrophage survival via repression of Bax and Bak.

Macrophages play an essential role in the innate immune response to infection and tissue injury. However, excessive macrophage activation may also significantly contribute to chronic inflammatory diseases. The Toll-like receptor (TLR) family are key regulators of innate immune responses in macrophages, and they are able to promote their survival and resistance against apoptosis.

Rounds reports: Early experiences of using printed summaries of electronic medical records in a large teaching medical hospital.

This article describes the rationale, processes, technology, and results of creating of a paper-based rounds report that is now used by our entire institution for efficient inpatient work rounds and checkout rounds that are routinely done in virtually every hospital, both academic and private, in the US. The results of a survey of clinicians suggests that printed rounds reports have markedly improved rounding efficiency, saved substantial amounts of physician time, standardized checkout processes, and improved patient safety.

ATF3 transcription factor and its emerging roles in immunity and cancer.

Activating transcription factor 3 (ATF3) is a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors. It is an adaptive-response gene that participates in cellular processes to adapt to extra- and/or intracellular changes, where it transduces signals from various receptors to activate or repress gene expression. Advances made in understanding the immunobiology of Toll-like receptors have recently generated new momentum for the study of ATF3 in immunity.