Quantifying the burden of hereditary hemorrhagic telangiectasia on quality of life and psychological health: a cross-sectional study.

Background: Despite the considerable burden that hereditary hemorrhagic telangiectasia (HHT) imposes, few studies have investigated its effect on health-related quality of life (HRQoL). We aimed to assess the impact of HHT on psychosocial QoL and identify demographic and clinical factors associated with lower QoL.

Methods: We conducted an international, cross-sectional study of 1042 adults with HHT within the Cure HHT network, between 2022 and 2023.

Binocular Alignment Changes Between Sitting and Supine Positions in Patients with Dizziness.

Vertical and torsional ocular misalignment can occur from mild traumatic brain injury or inner ear pathology, which may vary depending on head position. Here, we evaluate differences in a behavioral measure of binocular alignment in both upright and supine head position. Ocular perception of vertical and torsional alignment was measured using the torsional and vertical alignment nulling (TAN, VAN) task in N = 52 veterans with dizziness (N = 38 with traumatic brain injury), N = 41 civilians with vestibular schwannoma resection (UVD), and N = 33 healthy controls for both positions.

Elastic deformation of soft coatings due to lubrication forces.

Elastic deformation of rigid materials with soft coatings (stratified materials) due to lubrication forces can alter the interpretation of dynamic surface forces measurements and prevent contact formation between approaching surfaces. Understanding the role of elastic deformation on the process of fluid drainage is necessary, in particular for the case where one (or both) of the interacting materials consists of a rigid substrate with a soft coating. We combine lubrication theory and solid linear elasticity to describe the dynamic of fluid drainage past a compliant stratified boundary.