Publications by authors named "Matthew R Moldenhauer"
Article Synopsis
- Nonfunctional pituitary neuroendocrine tumors (PitNETs), especially silent corticotroph adenomas (SCAs), exhibit distinct growth patterns, with SCAs showing more aggressive invasion into areas like the sphenoid and cavernous sinuses.
- A study analyzed 91 patients who underwent surgery for nonfunctional PitNETs, comparing SCAs with other nonfunctional pituitary adenomas (NFPAs), finding significant differences in growth patterns.
- SCAs are more likely to invade bony structures, while NFPAs tend to grow into the suprasellar space, leading to varying clinical challenges in treatment strategies.
Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor progression. Here, we show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells.
View Article and Find Full Text PDFCancer cells reprogram their metabolism to meet elevated energy demands and favor glycolysis for energy production. This boost in glycolytic flux supports proliferation, but also generates acid in the form of hydrogen ions that must be eliminated from the cytoplasm to maintain the alkaline intracellular pH (pHi) associated with transformation. To cope with acid production, tumor cells employ ion transport systems, including the family of sodium-hydrogen exchangers (NHE).
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