Antibacterial and Cytotoxic Actinomycins Y-Y and Zp from Streptomyces sp. Strain Gö-GS12.

Four new Y-type actinomycin analogues named Y-Y (1-4) were isolated and characterized from the scale-up fermentation of the Streptomyces sp. strain Gö-GS12, as well as actinomycin Zp (5), which was, for the first time, isolated as a natural product. Structures of the new compounds were elucidated by the cumulative analyses of NMR spectroscopy and HRMS.