Publications by authors named "Matthew R Byrd"
Synthesis and immunostimulatory activity of substituted TLR7 agonists.
Bioorg Med Chem Lett
September 2016
Article Synopsis
- Researchers created fifteen new compounds based on adenine to test their effectiveness as TLR7 agonists, which can activate immune responses.
- These new compounds were studied alongside nine others that had been reported earlier to examine their ability to stimulate B cell proliferation.
- Some of these modified adenine derivatives showed promising activity, indicating they could potentially serve as useful vaccine adjuvants to enhance immune responses.
Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.
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