Formulae to correct sodium concentrations for serum water fraction in cases of hypo- and hyperproteinemia in cats.

Background: Biochemistry analyzers in many high-throughput laboratories use indirect potentiometry to determine serum electrolyte concentrations, which involves a pre-analytical dilution step that may be associated with artifactual increases or decreases in electrolyte concentrations under circumstances of altered serum water fraction (SWF). Severe hypo- and hyperproteinemia, conditions that cause altered SWF, are recognized but under-emphasized causes of falsely measured serum sodium concentrations.

Objectives: The goals of this study were to determine the average actual SWF (SWF ) and establish formulae to correct serum sodium concentration measured by indirect potentiometry in hypo- and hyperproteinemic cats.

Clinically healthy overweight and obese dogs differ from lean controls in select CBC and serum biochemistry values.

Background: Obesity is a global disease, affecting nearly half a billion people. Unfortunately, this trend is mirrored in our canine population.

Objectives: As obesity is a complex inflammatory disease, there is a need to determine whether routine medical screening tests may indicate, or be influenced by, its presence.

Hematology and biochemistry of aging-evidence of "anemia of the elderly" in old dogs.

Background: Effects of aging on hematologic and biochemical variables are well described in people. Anemia of the elderly is attributed to iron deficiency, anemia of chronic disease, chronic kidney disease, myelodysplasia, or idiopathic causes. Limited studies have examined these variables in aging dogs, but they have typically examined single breeds in research settings.