Publications by authors named "Matthew P Blakley"
Families with multiple individuals with acute leukemia in their pedigrees.
J Investig Med
December 2024
Forty-one families with multiple cases of de novo acute myeloid leukemia (AML), B-cell acute lymphocytic leukemia (B-ALL), or both are presented. The families were randomly collected from physicians, genetic counselors, and other sources. Medical records were collected and reviewed for all families.
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- There is growing evidence that Langerhans cell histiocytosis (LCH), acute myeloid leukemia (AML), and primary idiopathic myelofibrosis (MF) originate from the same type of myeloid precursor cell.
- The research involved analyzing over 750 family trees related to blood cancers and found one family with cases of LCH, AML, and MF across several generations.
- The study identifies patterns such as increased occurrences of these conditions in the family, suggesting a hereditary link, with certain patients showing earlier onset of diseases in successive generations.