Selenium abates manganese-induced striatal and hippocampal toxicity via abrogation of neurobehavioral deficits, biometal accumulation, oxidative stress, inflammation, and caspase-3 activation in rats.

Excessive exposure to manganese (Mn) is associated with neurotoxicity characterized by oxidative stress, inflammation, and apoptosis induction. Selenium (Se) has been shown to possess antioxidant, anti-inflammatory, and anti-apoptotic properties in humans and animals. The present study investigated the neuroprotective mechanism of Se in rats sub-chronically treated with Mn at 30 mg/kg body weight or orally co-treated with Se at 0.

Ethanol exacerbates manganese-induced oxidative/nitrosative stress, pro-inflammatory cytokines, nuclear factor-κB activation, and apoptosis induction in rat cerebellar cortex.

Manganese (Mn) exposure is causing public health concerns as well as heavy alcohol consumption. This study investigates the mechanisms of neurotoxicity associated with Mn and ethanol (EtOH) exposure in the rat cerebellar cortex. Experimental animals received 30 mg/kg of Mn alone, 5 g/kg of EtOH alone, co-exposed with 30 mg/kg of Mn and 1.

Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis.

Manganese (Mn) is an essential nutrient element. However, Mn is causing great environmental and occupational exposure health risk concern globally, even high rate of alcohol consumption. There is dearth of scientific information on the interaction of manganese (Mn) and ethanol (EtOH) on hippocampal functions.

Ethanol Exacerbates Manganese-Induced Neurobehavioral Deficits, Striatal Oxidative Stress, and Apoptosis Via Regulation of p53, Caspase-3, and Bax/Bcl-2 Ratio-Dependent Pathway.

This study investigated the effects of ethanol (EtOH) on manganese (Mn)-induced striatal toxicity in rat by evaluating the neurobehavioral changes, biochemical and molecular events in rats exposed to Mn alone at 30 mg/kg, or their combination with EtOH at 1.25- and 5-g/kg body weight for 35 consecutive days. Locomotive and exploratory profiles were assessed using a video tracking software (ANY-Maze software) during a 5-min trial in a novel environment.

Ethanol via Regulation of NF-κB/p53 Signaling Pathway Increases Manganese-Induced Inflammation and Apoptosis in Hypothalamus of Rats.

The diet is a major route of manganese (Mn) exposure for humans. Interestingly, several epidemiological data demonstrated an increase in the incidence of alcohol consumption globally. Chemical-chemical interaction subsequent to chemical mixtures exposure may result in a synergism or antagonism effects.

Levels of Some Heavy Metals and Health Risks Assessment of Three Different Species of Catfishes in Ikoli Creek, Bayelsa State, Nigeria.

Heavy metals are the most common form of aquatic pollutants and are of great health risk to consumers of contaminated sea food. This study investigated the level of heavy metals in three species of catfishes Chrysichthys nigrodigitatus (marine catfish), Clarias gariepinus (African catfish), and Schilbe mystus (silver catfish) in Ikoli Creek, Bayelsa State. The potential human health risks to consumers in the study area were investigated.

Ethanol exacerbates manganese - induced functional alterations along the hypothalamic-pituitary-gonadal axis of male rats.

Manganese (Mn) exposure has been reported to induce reproductive dysfunction in animal and humans. Studies have shown that a large percentage of adolescent and adult populations tend to consume alcohol in a binge pattern. However, there is no information on the influence of alcohol on Mn - induced functional alteration along the hypothalamic - pituitary - gonadal axis.

Trace metal contents of selected seeds and vegetables from oil producing areas of Nigeria.

The concentrations of accumulated trace metals in selected seeds and vegetables collected in the oil producing Rivers State of Nigeria were investigated. The values were compared with those of seeds and vegetables cultivated in Owerri, a less industrialized area in Nigeria. The lead (Pb) and cadmium (Cd) contents of the seeds obtained from Rivers State ranged between 0.

Characterization and safety evaluation of the impact of hydrocarbon contaminants on ecological receptors.

Hydrocarbon-contaminant removal efficiency of Bambara groundnuts and biomagnification was investigated. The crude oil contaminated soil samples in which the plants were established were either un-amended, or amended with NPK, or Urea, or Poultry manure. Amendments improved phytoextraction rates as follows: Urea - 63.

Trace-metal contamination of the African giant land snail Archachatina marginata from Southern Nigeria.

The levels of bio-accumulated trace metals in the African giant land snail Archachatina marginata, collected in six different states of Southern Nigeria, were determined. The Cu and Fe levels were 3.0-9.

Assessment of heavy-metal profile of the New Calabar River and its impact on juvenile Clarias gariepinus.

We have determined the heavy-metal status of the lower reaches of the New Calabar River in the Niger Delta region over a 40-km-long distance, and its impact on the development of catfish (juvenile Clarias gariepinus). The total mean concentrations of dissolved trace metals in the river were 0.01, 0.